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Methyl B-12 Injections For Your Autistic Child

Methyl B-12 Shots - MB12 Pre-filled syringes

Methyl B-12 Pre-Filled Syringes

When we first found out our son was on the Autism Spectrum, one of the first biomedical interventions we wanted to try was Methyl B-12 shots.

According to Dr. Neubrander, a well-known autism pediatric physician in New Jersey who pioneered the use of MB12 shots in the autism population, this is one of the first and most effective treatments to try.  My understanding from talking to Rick Neubrander, at the office, is that Dr. Neubrander prescribes a trial of these shots for all his autistic patients, the first time they come to see him, even before blood work is back.

Here’s a great video by Autism Dad, Phil Commander, sharing his son Jake’s Experience on MB-12 Shots

Here Are Some Common Questions About MB-12 Shots:

How much do MB-12 shots Cost?

This will obviously depend on how much your pharmacy charges, but for us, they average $10 per shot. We buy them as pre-filled syringes from a compounding pharmacy – the Falls Pharmacy in Snoqualmie, WA.  They ship to us chilled with Fed Ex overnight shipping which is $15.  We buy 3-months of shots at a time to save on the shipping charges.

How Do You Administer MB-12 Shots?

The Methyl B-12 injections should be given in the fat of the bottom.  The needle is only about 3 millimeters long, so it doesn’t go very deep into the muscle, in any event, but your main goal is to inject it at a very shallow angle – inject it sideways, just under the skin, not perpendicular.

It’s a good idea to clean the skin ahead of time.  You can also apply a numbing cream, 20 minutes in advance, to prepare the area.  What I would recommend using that the first  couple of times, but after your child is accustomed to the routine, it shouldn’t be necessary.  For children who are very sensitive, you might need to give the injection late at night, while they are sleeping.

This Video Shows How To Give A Methyl B-12 Injection:

How Do You Know If MB-12 Shots Are Working For Your Child?

It can be hard to tell if your child is a “responder” to the MB-12 shots.  Dr. Neubrander has developed an exhaustive parent survey/inventory to see if you notice any changes in your child while he is on the shots.  Often, the initial results are subtle.  Even if your results are subtle at first, if you are a “responder” it’s good to stay on the shots, as the results will increase over time.

Many children experience a change in behavior that their parents view as negative – for example – hyperactivity, hitting, or acting out. Even though we don’t want these behaviors to persist, they can be viewed as a good sign that the shots are having an impact.

Here is an article from Dr. Neubrander on How To Tell If MB-12 Shots Are Working For Your Child.

How Long Do You Have to Stay on MB-12 Shots?

Many people end up staying on the MB-12 shots for 2-3 years, but these are available by prescription only, so you’ll want to work this out with your doctor.

Why Do MB-12 Shots Work?  What is the Mechanism of Action?

Many people have a shortage of MB-12 in their bodies. Many children with autism have metabolic deficiencies due to various MTHR gene variations that make it harder for their metabolic methylation pathways to function correctly. My doctor explained this as trying to ride a bicycle that has square wheels instead of round ones. It can be harder to get the metabolism wheel spinning, and keep it spinning. In the case of autism, this defecit often presents with neurological symptoms.

This book, Could It Be B12?: An Epidemic of Misdiagnoses, gives an even broader view of different medical problems that can result from vitamin B-12 deficiencies.

What Are The Side Effects of Methyl B-12 Shots?

I was worried when I first started giving MB-12 that I might “overdose” my son with the vitamin, if he was not, in fact deficient. As it turns out, this is not a danger or concern, as long as you follow the dosages specified and administer the pre-filled syringes on the prescribed schedule.

However, you may notice behavior changes in your child that could be considered negative side effects. Generally, these are a function of becoming more “aware” of the environment, or more active/agitated. Side effects can include things like hyperactivity, and aggression. They are mostly “behavior” related, rather than negative health effects.

Are Mehtyl B-12 Injections Safe?

In my opinion, yes. These are very safe, and my understanding is that Dr. Neubrander puts all his autistic patients on a 6-week trial of MB-12 (dose based on weight) the first time they come into his office. He may be a bit biased, because he pioneered the use of this treatment in autism, and sees a 94% response rate in his patients, however, if there were significant health concerns to be worried about, he would probably not prescribe this so liberally.

If your child is on the ASD spectrum, and you can afford the shots (about $100/month, depending on your dosage schedule/provider, etc.) then this is definitely a good one to try. Some people get “miraculous” overnight results, but even if you don’t, the long term use of the MB-12 therapy may still be very helpful for your ASD patient.

Please Add Your Questions In The Comments Below and I will work on expanding this post with additional information.


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  1. Pingback: Find A Holistic DAN Doctor in Seattle To Help Your Autistic Child

  2. Aisha says:

    Hello doctor my son is 2yrs 5months old.. he has been diagnosed with ASD. Can u pls prescribe me.the best mb 12 shots for my son as i live in india. Or can u ship me also. Please help me doctor.

    • admin says:

      Hi Aisha,

      What I have actually read more recently than when I published this article, is that although some children do well on Methyl-B12 shots, they can actually feed the parasites that infect many of our autistic children.

      When I first heard this theory, I thought that parasites were only a problem in poor areas, or areas of low sanitation. But I have come to find out that they affect autistic children all over the world, even here in Seattle, WA!

      Rather than starting on Methyl-B-12 shots, I now recommend starting with Kerri Rivera’s book: Healing The Symptoms Known as Autism. It’s available on Amazon here: Healing The Symptoms Known As Autism – By Kerri Rivera

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